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KMID : 0356720020180050311
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Journal of the Korean Society of Coloproctology
2002 Volume.18 No. 5 p.311 ~ p.316
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Correlation of β-catenin and p53 Protein Expression with Clinico-pathologic Characteristics of Colorectal Cancer
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Moon Kil-Min
Park Young-Jin
Kim Han-Seong
Park Seong-Hye
Kim Ji-Il
Kim Ki-Hong
Song Byung-Joo
Lee Myung-Soo
Kim Chul-Nam
Chang Surk-Hyo
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Abstract
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Purpose: Both the β-catenin and p53 play a crucial role in the process of colon carcinogenesis. The expression of β-catenin and/or p53 has been reported to be associated with pathologic features of tumor and prognosis of patients. In
addition, several recent studies have suggested a close biological association between p53 expression and nuclear β-catenin level. We analyzed the pathologic variables and p53 expression according to the intra-nuclear β-catenin expression in colon cancer to make such assumptions more clear since they are still controversial issues.
Methods: The expressions of β-catenin, p53 and Ki-67 protein in colon cancer were determined by immunohistochemical staining. The relationship between these protein expressions and tumor characteristics was statistically analyzed.
Results: The intra-nuclear β-catenin accumulation was not associated with any of the pathological variables including lymph node metastasis and tumor differentiation, but it was correlated with higher level of Ki-67 proliferation index
(P=0.006) and negative staining of p53 (P =0.015). Positive p53 staining was significantly associated with lymph node metastasis (P=0.006), lymphatic invasion (P=0.03) and venous invasion (P=0.02).
Conclusion: These results support the suggestion that intra-nuclear accumulation of β-catenin may regulate the p53 activity in colorectal cancer. In addition, positive staining of p53 may be used as a valuable prognostic indicator since
it was strongly associated with lymph node metastasis, lymphatic and venous invasion.
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KEYWORD
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Colorectal cancer, β-catenin, p53, Lymph node metastasis, Differentiation
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